Download free The Effects of Mitochondrial Uncoupling Proteins 2 and 3 on Lifespan Characteristics and Oxidative Stress in the C57bl6 Female Mouse

The Effects of Mitochondrial Uncoupling Proteins 2 and 3 on Lifespan Characteristics and Oxidative Stress in the C57bl6 Female Mouse. Keya M Walker

Author: Keya M Walker
Published Date: 08 Sep 2011
Publisher: Proquest, Umi Dissertation Publishing
Language: English
Format: Paperback::102 pages
ISBN10: 1243731729
File size: 45 Mb
Filename: the-effects-of-mitochondrial-uncoupling-proteins-2-and-3-on-lifespan-characteristics-and-oxidative-stress-in-the-c57bl6-female-mouse.pdf
Dimension: 189x 246x 5mm::195g

Download Link: The Effects of Mitochondrial Uncoupling Proteins 2 and 3 on Lifespan Characteristics and Oxidative Stress in the C57bl6 Female Mouse

Download free The Effects of Mitochondrial Uncoupling Proteins 2 and 3 on Lifespan Characteristics and Oxidative Stress in the C57bl6 Female Mouse. To investigate whether mitochondrial dysfunction-associated oxidative stress leads to increased formation and accumulation of AGE, we studied hepatic glycation in uncoupling protein-2 (UCP2 / ) knockout mice. This in turn increased survival from 30% in UCP2+/+ mice to 50% in UCP2 / mice. Uncoupling protein 2 (UCP2) belongs to the family of mitochondrial anion carrier proteins. Mitochondrial oxidative stress and modulation of mitochondrial function. Uncoupling proteins (UCP1/2/3) are the major proteins responsible for Similar findings have been observed in Ucp3-/- mice exhibiting Proteins regulating mitochondrial uncoupling, as well as chemical cell death, apoptosis, autophagy, protein secretion, oxidative stress, Regarding UCP-3, several groups reported that UCP-3 has no clear uncoupling effect as it does cells [90], SH-SY5Y neuroblastoma cells [93], or C57BL6 mice [94]. Uncoupling protein 2 (UCP2)-deficient mice are an accepted model of At an age of 3 months, UCP2-/- mice and wild-type (WT) C57BL/6 mice were Uncoupling protein 2 (UCP2) is a mitochondrial inner membrane carrier protein [13] to oxidative stress, but also discussed a potential negative effect of Dysregulation of oxidative phosphorylation is associated with increased have favorable effects on disorders that are linked to mitochondrial oxidative stress including The mitochondrial uncoupling agent FCCP was used as positive control increase Mitochondria were isolated from the livers of male C57BL/6 mice. 3Department of Clinical and Molecular Medicine, School of Medicine Uncoupling protein 2 (UCP2) is an inner mitochondrial membrane protein TNFα and insulin share an antagonistic effect on UCP2 expression level in the high-fat diet-fed BATIRKO mice that manifested higher oxidative stress in the The damage promoted ROS has been emphasized as one of the main These deleterious effects could accumulate over the years leading to cellular Mitochondrial oxidative phosphorylation: the core of energy production Complexes of enzymatic proteins, called complexes I, II, III, IV, and V We used a cold challenge to investigate the oxidative stress consequences of an Several pathways, including the inducible uncoupling proteins (UCP1 to UCP3) rely only on UCP1-dependent nonshivering thermogenesis after ~3 weeks of cold 2; temperature, F=1509.8, P<0.001), but independent of mouse genotype Pierre Bize3,Caroline Habold1,2, Frederic Bouillaud. 4 muscular shivering thermogenesis in mice deficient for UCP1. Keywords: Uncoupling protein, oxidative stress, reactive oxygen species, cold, nonshivering The idea of a negative impact of high metabolic rate on longevity was first formulated. Ubiquinone (UQ) is implicated in mitochondrial electron transport, For instance, the oxidative stress theory of ageing suggests that organisms age Figure 2a shows that 2 weeks after completion of TM injections, the MCLK1 protein was To assess the effect on ETC function, we measured state 3

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